At a very general level, the seminar will cover our research into the physical and structural mechanisms of antimicrobial peptide (AMP) killing of bacteria. Our main techniques are solution and solid state NMR, along with molecular dynamics simulation and calorimetry. We are particularly interested in finding ways to extend these approaches beyond model systems to the actual, complex biological systems. To this end, we have developed biophysical approaches to study AMPs interacting with intact bacteria, which complement the more detailed information gleaned from the model systems. AMPs form a class of molecules that is of wide interest, in part due to its importance in the immune system and in part due to its potential as a basis for novel antimicrobial and cancer drugs.
Professor Vladimir Ladizhansky