Advances in nanotechnology are leading to exciting new developments in biological and medical applications. Strategies that can reproducibly prepare colloidal nanostructures of a wide range of geometries with a tight size distribution have been achieved and unique size and shape dependent optical, magnetic, electrical, and biological properties have been discovered. The simplicity of tuning the geometry of a nanostructure during synthesis to produce a material with unique properties can create a large library of raw materials. Researchers from diverse backgrounds have now started to use them in a variety of applications, such as contrast probes in imaging applications, components in microscale devices for high throughput multiplex detection, delivery vehicles for enhancing drug payload, precursors in light emitting diode, and components in computer chip. Despite the promise and potential, nanotechnology is still a very young field that requires further development, especially when nanotechnology is applied to biology and medicine. The focus of this seminar will be on quantum dots for cell and animal imaging applications. Specifically, we will focus on strategies to overcome the delivery strategies of quantum dots in cells and animals.