Physics Colloquium: Understanding clonal composition of repopulating blood

Event Details

  • Speaker(s): Professor Sidhartha Goyal
  • Date:
  • Time: 4:00 PM
  • Location: MacN 101

Abstract

Much of complex biology results from interactions among a large number of individually simpler elements. Blood regeneration is no different. About 100 billion new blood cells are made everyday from a much smaller yet a large population of diverse stem cell population. I will present a coarse-grained model of blood regeneration, which provides a framework to understand large variations (~3 orders of magnitude) among contributions from individual stem cells. We show that a combination of slow stem cell differentiation followed by a bursty amplification is at the heart of this observed variability. With our model we develop a counter hypothesis to the role of cell-level differences as an explanation for the large variability.