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Home > Molecular Biophysics (PHYS*4540)

Molecular Biophysics (PHYS*4540)

Course code: 
PHYS*4540
Section: 
01
Course term: 
Winter 2018
Course instructor: 
Vladimir Ladizhansky
Details: 

Course Information

Instruction

Lecturer Office Extension Email
Vladimir Ladizhansky SSC 1251 53989 vladizha@uoguelph.ca

Course Topics

  • Protein structure. Nucleic acids structure. Factors determining protein and nucleic acid structures. Protein Stability. Biomembranes. Membrane proteins and their functions. Membrane transport. Evolution and Protein Folding. Human perspective: conformational diseases.
  • Various topics in structural biology and biophysics of proteins. (Students’ presentations)
  • Nuclear Magnetic Resonance (NMR) and high resolution structure determination in biomolecules. Fundamentals of the NMR. Multidimensional NMR spectroscopy. Brief Introduction into NMR-based structure determination. Spectral Assignments. Determination of structural constraints. NOE effect. Constraint-based calculation of structure. Solid-state NMR and protein structure determination.
  • Applications of NMR to various problems in structural biophysics. (Students' presentations)

Evaluation

Assessment Weight
Participation in discussions 5%
Assignments 25%
Presentations
Students will be asked to give two presentations
40%
Papers/Projects
Students will have to write a research proposal based on one of their presentations.
30%

Course Materials

Textbooks

  • Lodish et al, “Molecular Cell Biology” 5th edition
  • Charles R. Cantor and Paul R. Schimmel: “Biophysical chemistry” part I: The conformation of biological molecules.
  • Additional literature (papers, lecture notes, links to online materials, etc.) will be distributed.

Recommended Literature

  • Thomas E. Creighton, “Proteins: Structure and Molecular Properties”
  • Karp, “Cell and Molecular Biology”
  • Voet and Voet, “Biochemistry”
  • Stryer, “Biochemistry”
  • Alberts, "Molecular Biology of the Cell"

Course Policies

Academic Misconduct

The University of Guelph takes a serious view of academic misconduct and will severely penalize students, faculty and staff who are found guilty of offenses associated with misappropriation of others' work, misrepresentation of personal performance and fraud, improper access to scholarly resources, and obstructing others in pursuit of their academic endeavours. Each student is assumed to be familiar with the regulations surrounding academic misconducts, as spelled out in the Undergraduate Calendar.

Department Resources

Course Outlines
Physics Tutorials

Machine Shop
Machine Shop Requisition Form

Poster Boards

NMR Centre

The Observatory is not available for public visits at this time.

Administrative Links

Campus Directory
Gryph Mail
Physics Intranet
Employee Portal
Illness or Injury Incident Report
Undergraduate Calendar
Graduate Calendar
CUPE 3913

Contact Us

Department Chair: Dr. Stefan Kycia
Administrative Officer: Rachel Baker
IT Help: phys-it-help@uoguelph.ca
Other Inquiries: physinfo@uoguelph.ca

Department of Physics, Main Office
MacNaughton Building, Room 207
1-519-824-4120 x 52261

Courier to:
488 Gordon Street
Physics, Science Complex, Rm 1110
Guelph, ON | N1G 2W1


Source URL:https://www.physics.uoguelph.ca/course-outlines/molecular-biophysics-phys4540-3