Biological Nano Materials (NANO*4100)
Code and section: NANO*4100*01
Term: Fall 2022
Instructor: Vladimir Ladizhansky
|Vlad Ladizhansky||SSC firstname.lastname@example.org|
Office Hours: Please contact the instructor directly.
|Tue/Thu,||8:30 am-9:50 am||MCKN, Room 059|
*First lecture: Thursday, September 8th
There is no required text for this course. The following texts may be useful:
- Jones, Soft Machines: Nanotechnology and Life
- Lodish et al, Molecular Cell Biology
- Creighton, Proteins: Structure and Molecular Properties
- Additional literature (papers, lecture notes, links to online materials, etc.) will be distributed.
- Biological molecules and interactions
- Review of basic chemistry concepts. Covalent and non-covalent interactions. Types of interactions- electrostatics, van der Waals interactions, hydrophobicity, steric effects, solvation. Electronegativity, hydrogen bonding, pH.
- Amino acids and their properties. Primary, secondary, tertiary and quaternary structure of proteins. Factors and interactions determining the different levels of structure.
- Nucleic acids. Structures of DNA and RNA. Interactions determining nucleic acid structures. Watson-Crick base pairing.
- Molecular self-assembly
- Formation of detergent micelles. Formation of lipid bilayers and liposomes. Biological membranes. Membrane proteins.
- Molecular “nanomachines”: ATPases, ion channels, and transporters, molecular motors.
- Peptide and protein misfolding. Formation of amyloid fibrils and lessons that can be learned from this – novel peptide based nanomaterials with applications.
- Nanobiomaterials with applications.
- DNA nanotechnologies. Metallic nanoparticle-based nanobiomaterials. Imaging and contrast agents. Semiconductor-, ceramic-, protein-, polymer-based nanobiomaterials. Biologically-directed/self-assembled nanobiomaterials. Viruses. Biosensors.
Students will be asked to give three presentations.
Topics for presentations will be distributed in advance.
Students will have to write a research proposal based on one of their presentations.
|Participation in discussions||4%|
Course Assessment by Students
The Department of Physics requires student assessment of all courses taught by the Department. These assessments provide essential feedback to faculty on their teaching by identifying both strengths and possible areas of improvement. In addition, annual student assessment of teaching provides part of the information used by the Department Tenure and Promotion Committee in evaluating the faculty member's contribution in the area of teaching.
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Copies of Out-of-class Assignments
Keep paper and/or other reliable back-up copies of all out-of-class assignments: you may be asked to resubmit work at any time.
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Recording of Materials
Presentations that are made in relation to course work - including lectures - cannot be recorded or copied without the permission of the presenter, whether the instructor, a student, or guest lecturer. Material recorded with permission is restricted to use for that course unless further permission is granted.
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