Biological Nano Materials (NANO*4100)
Code and section: NANO*4100*01
Term: Fall 2023
Department of Physics
College of Engineering and Physical Sciences
NAN0*4100: Quantum Mechanics I
Fall 2023 (LEC: 3) [0.50]
Biological systems provide a rich range of examples of specialized chemical systems that are structured on the nanoscale. Nanofibres, microtubules, viruses, and ribosomes are examples of systems that can be studied from the perspective of nanoscience. Using these systems or developing artificial systems which mimic their functionality are important growth areas in nanoscience and will be explored in this course.
Prerequisite(s): MATH*2270, (CHEM*2820 or PHYS*2240)
Department(s): Department of Physics
For Course Instructor, Class Time and Location, please check CourseLink.
There is no required text for this course. The following texts may be useful:
- Jones, Soft Machines: Nanotechnology and Life
- Lodish et al, Molecular Cell Biology
- Creighton, Proteins: Structure and Molecular Properties
- Additional literature (papers, lecture notes, links to online materials, etc.) will be distributed.
1. Biological molecules and interactions
- Review of basic chemistry concepts. Covalent and non-covalent interactions. Types of interactions- electrostatics, van der Waals interactions, hydrophobicity, steric effects, solvation. Electronegativity, hydrogen bonding, pH.
- Amino acids and their properties. Primary, secondary, tertiary and quaternary structure of proteins. Factors and interactions determining the different levels of structure.
- Nucleic acids. Structures of DNA and RNA. Interactions determining nucleic acid structures. Watson-Crick base pairing.
2. Molecular self-assembly
- Formation of detergent micelles. Formation of lipid bilayers and liposomes. Biological membranes. Membrane proteins.
- Molecular “nanomachines”: ATPases, ion channels, and transporters, molecular motors.
- Peptide and protein misfolding. Formation of amyloid fibrils and lessons that can be learned from this – novel peptide based nanomaterials with applications.
3. Nanobiomaterials with applications.
- DNA nanotechnologies. Metallic nanoparticle-based nanobiomaterials. Imaging and contrast agents. Semiconductor-, ceramic-, protein-, polymer-based nanobiomaterials. Biologically-directed/self-assembled nanobiomaterials. Viruses. Biosensors.
- Assignments: 20%.
- Quizzes: 6%
- Presentations: 45%. Topics for presentations will be distributed in advance.
- Papers/Projects: 25%. Students will have to write a research proposal based on one of their presentations.
- Participation in discussions: 4%
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The last date to drop one-semester courses, without academic penalty, is 1 December 2023. For regulations and procedures for Dropping Courses, see the Undergraduate Calendar.