Molecular Biophysics (PHYS*4540)
Code and section: PHYS*4540*01
Term: Winter 2021
Instructor: Vladimir Ladizhansky
Lecturer contact information
Tuesday/Thursday, 11:30 am-12:50 pm, AD-S (Synchronous virtual)
ZOOM LINK WILL BE PROVIDED.
- Protein structure. Nucleic acids structure. Factors determining protein and nucleic acid structures. Protein Stability. Biomembranes. Membrane proteins and their functions. Membrane transport. Evolution and Protein Folding. Human perspective: conformational diseases.
- Various topics in structural biology and biophysics of proteins. (Students’ presentations)
- Nuclear Magnetic Resonance (NMR) and high resolution structure determination in biomolecules. Fundamentals of NMR. Multidimensional NMR spectroscopy. Brief introduction into NMR-based structure determination. Spectral Assignments. Determination of structural constraints. Constraint-based calculation of structure. Protein dynamics.
- Applications of NMR to various problems in structural biophysics. (Students' presentations)
- Participation in discussions: 5%.
- Quizzes: 9%
- Assignments: 30%.
- Presentations: 30%. Students will be asked to give three presentations
- Final proposal/paper: 26%. Students will have to write a research proposal based on one of their presentations.
- Lodish et al, “Molecular Cell Biology” 5th edition
- Charles R. Cantor and Paul R. Schimmel: “Biophysical chemistry” part I: The conformation of biological molecules.
- Additional literature (papers, lecture notes, links to online materials, etc.) will be distributed.
- Thomas E. Creighton, “Proteins: Structure and Molecular Properties”
- Karp, “Cell and Molecular Biology”
- Voet and Voet, “Biochemistry”
- Stryer, “Biochemistry”
- Alberts, "Molecular Biology of the Cell"
Course and University Policies
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Course Evaluation Information
The Department of Physics requires student assessment of all courses taught by the Department. These assessments provide essential feedback to faculty on their teaching by identifying both strengths and possible areas of improvement. In addition, annual student assessment of teaching provides part of the information used by the Department Tenure and Promotion Committee in evaluating the faculty member's contribution in the area of teaching.
The Department's teaching evaluation questionnaire invites student response both through numerically quantifiable data, and written student comments. In conformity with University of Guelph Faculty Policy, the Department Tenure and Promotions Committee only considers comments signed by students (choosing "I agree" in question 14). Your instructor will see all signed and unsigned comments after final grades are submitted. Written student comments may also be used in support of a nomination for internal and external teaching awards.
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The last date to drop one-semester courses, without academic penalty, is April 12, 2021. For regulations and procedures for Dropping Courses, see the Undergraduate Calendar.
Please note that the ongoing COVID-19 pandemic may necessitate a revision of the format of course offerings and academic schedules. Any such changes will be announced via CourseLink and/or class email. All University-wide decisions will be posted on the COVID-19 website and circulated by email.
The University will not require verification of illness (doctor's notes) for the Fall 2020 or Winter 2021 semesters.