Molecular Biophysics (PHYS*4540)
Code and section: PHYS*4540*01
Term: Winter 2018
Instructor: Vladimir Ladizhansky
|Vladimir Ladizhansky||SSC email@example.com|
- Protein structure. Nucleic acids structure. Factors determining protein and nucleic acid structures. Protein Stability. Biomembranes. Membrane proteins and their functions. Membrane transport. Evolution and Protein Folding. Human perspective: conformational diseases.
- Various topics in structural biology and biophysics of proteins. (Students’ presentations)
- Nuclear Magnetic Resonance (NMR) and high resolution structure determination in biomolecules. Fundamentals of the NMR. Multidimensional NMR spectroscopy. Brief Introduction into NMR-based structure determination. Spectral Assignments. Determination of structural constraints. NOE effect. Constraint-based calculation of structure. Solid-state NMR and protein structure determination.
- Applications of NMR to various problems in structural biophysics. (Students' presentations)
|Participation in discussions||5%|
Students will be asked to give two presentations
Students will have to write a research proposal based on one of their presentations.
- Lodish et al, “Molecular Cell Biology” 5th edition
- Charles R. Cantor and Paul R. Schimmel: “Biophysical chemistry” part I: The conformation of biological molecules.
- Additional literature (papers, lecture notes, links to online materials, etc.) will be distributed.
- Thomas E. Creighton, “Proteins: Structure and Molecular Properties”
- Karp, “Cell and Molecular Biology”
- Voet and Voet, “Biochemistry”
- Stryer, “Biochemistry”
- Alberts, "Molecular Biology of the Cell"
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