Molecular Biophysics (PHYS*4540)
Code and section: PHYS*4540*01
Term: Winter 2018
Instructor: Vladimir Ladizhansky
Details
Course Information
Instruction
| Lecturer | Office | Extension | |
|---|---|---|---|
| Vladimir Ladizhansky | SSC 1251 | 53989 | vladizha@uoguelph.ca |
Course Topics
- Protein structure. Nucleic acids structure. Factors determining protein and nucleic acid structures. Protein Stability. Biomembranes. Membrane proteins and their functions. Membrane transport. Evolution and Protein Folding. Human perspective: conformational diseases.
- Various topics in structural biology and biophysics of proteins. (Students’ presentations)
- Nuclear Magnetic Resonance (NMR) and high resolution structure determination in biomolecules. Fundamentals of the NMR. Multidimensional NMR spectroscopy. Brief Introduction into NMR-based structure determination. Spectral Assignments. Determination of structural constraints. NOE effect. Constraint-based calculation of structure. Solid-state NMR and protein structure determination.
- Applications of NMR to various problems in structural biophysics. (Students' presentations)
Evaluation
| Assessment | Weight |
|---|---|
| Participation in discussions | 5% |
| Assignments | 25% |
| Presentations Students will be asked to give two presentations |
40% |
| Papers/Projects Students will have to write a research proposal based on one of their presentations. |
30% |
Course Materials
Textbooks
- Lodish et al, “Molecular Cell Biology” 5th edition
- Charles R. Cantor and Paul R. Schimmel: “Biophysical chemistry” part I: The conformation of biological molecules.
- Additional literature (papers, lecture notes, links to online materials, etc.) will be distributed.
Recommended Literature
- Thomas E. Creighton, “Proteins: Structure and Molecular Properties”
- Karp, “Cell and Molecular Biology”
- Voet and Voet, “Biochemistry”
- Stryer, “Biochemistry”
- Alberts, "Molecular Biology of the Cell"
Course Policies
Academic Misconduct
The University of Guelph takes a serious view of academic misconduct and will severely penalize students, faculty and staff who are found guilty of offenses associated with misappropriation of others' work, misrepresentation of personal performance and fraud, improper access to scholarly resources, and obstructing others in pursuit of their academic endeavours. Each student is assumed to be familiar with the regulations surrounding academic misconducts, as spelled out in the Undergraduate Calendar.